Using evolution to generate sustainable malaria control with spatial repellents

Using evolution to generate sustainable malaria control with spatial repellents

Blog Article

Evolution persistently undermines vector control programs through insecticide resistance.Here we propose a novel strategy which instead exploits evolution to generate and sustain new control tools.Effective spatial repellents are needed to keep vectors out of houses.

Our approach click here generates such new repellents by combining a high-toxicity insecticide with a candidate repellent initially effective against only part of the vector population.By killing mosquitoes that enter treated properties the insecticide selects for vector phenotypes deflected by the repellent, increasing efficacy of the repellent against the target vector population and in turn protecting the insecticide against the spread of insecticide resistance.Using such evolved spatial repellents offers an evolutionarily sustainable, ‘double-dip’ system of disease control combining mortality and repellence.

We formalize this idea using models which explore vector population genetics and disease transmission probabilities and show that using evolved spatial repellents is rumchata proof theoretically achievable, effective and sustainable.